反应详情

温度

220 °C

To a solution of 0.40 g 6-bromo-4-methoxy-pyridin-2-ylamine in 8.0 ml dimethylformamide was added 0.265 g copper(I) cyanide and the mixture was heated to 220° C. under microwave irradiation for 6 min. The reaction mixture was partitioned between water and ethyl acetate. The phases were separated and washed with water and brine, dried over magnesium sulfate dihydrate and purified by chromatography on silica gel with heptane : ethyl acetate to yield 0.086 g of the title compound as greenish solid MS (ISP) M+H+=183.1

1. customThe reaction mixture was partitioned between water and ethyl acetate
2. customThe phases were separated
3. washwashed with water and brine
4. dry with materialdried over magnesium sulfate dihydrate
5. custompurified by chromatography on silica gel with heptane