Sodium Hydroxide → 5-(2-Hydroxyethyl)-4-methyl-N-{[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}thiophene-2-sulfonamide

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Reaction Steps

To a solution of 0.25 g 2-{3-methyl-5-[({[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}amino)sulfonyl]-2-thienyl}ethyl acetate in 5 ml methanol was added 0.01 ml 28% aqueous sodium hydroxide and the mixture was kept at room temperature for 3 h. The reaction mixture was partitioned between 10% citric acid and ethyl acetate. The phases were separated and the organic phase was washed with brine and evaporated. The residue was triturated with t-butylmethyl ether/heptane to yield 0.177 g of the title compound as off white powder MS (ISN) M−H+=422.4.

Provenance & Evidence