Hydroxylamine → HCID 178513383, compound

HRID 1696802Notes

Reaction equation

HRID 1696802 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[C:3]=1[C:4]#[N:5].[NH2:12][OH:13]>CCO>[OH:13][NH:12][C:4](=[NH:5])[C:3]1[C:6]([F:11])=[CH:7][C:8]([F:10])=[CH:9][C:2]=1[F:1]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 7371772,4,6-Trifluorobenzonitrile

Product 1

HCID 178513383HCID 178513383, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2,4,6-trifluorobenzonitrile (1.5 g, 9.6 mmol) in EtOH (5 mL), hydroxylamine (50% wt. aqueous solution, 2.5 mL, 38 mmol) was added at room temperature and the solution was stirred under reflux for 1 h. The solvent was removed under reduced pressure to afford N-hydroxy-2,4,6-trifluoro-benzamidine that was used immediately for the next step.

Workup

  1. temperatureunder reflux for 1 h
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-21d09d9b8b394ead98d3ccf25623994d
Source dataset
uspto-grants-2012_04
Patent number
US08163775B2

Reaction notes

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