HCID 67275202, compound → HCID 10038383, compound

HRID 1696900Notes

Reaction equation

HRID 1696900 reaction equation
[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:29])[C:10]([C:26]([OH:28])=[O:27])=[CH:11][N:12]3CC3C=CC(OC)=CC=3OC)=[CH:7][C:6]=2[F:30])[CH2:4][CH2:3][CH2:2]1>FC(F)(F)C(O)=O>[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:29])[C:10]([C:26]([OH:28])=[O:27])=[CH:11][NH:12]3)=[CH:7][C:6]=2[F:30])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 67275202HCID 67275202, compound

Product 1

HCID 10038383HCID 10038383, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of EXAMPLE 7H (1 g) in trifluoroacetic acid (10 mL) was heated at 50° C. for 3 hours and concentrated; and the concentrate was azeotroped with toluene and triturated with acetonitrile. NMR (300 MHz, DMSO-d6) δ 15.51 (s, 1H), 13.28 (br s, 1H), 8.42 (s, 1H), 7.92 (m, 1H), 4.40-4.20 (m, 4H), 2.43 (m, 2H).

Workup

  1. concentrationconcentrated
  2. customand the concentrate was azeotroped with toluene
  3. customtriturated with acetonitrile

Sources & evidence

ORD record
ord-f10a999267664b74aad5879029e178ec
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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