3-Aminoazetidine, 3-BOC protected → HCID 67274679, compound

HRID 1696906Notes

Reaction equation

HRID 1696906 reaction equation
Cl[C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][N:9]2[CH2:12][CH2:13][C:14]#[N:15])=[CH:4][C:3]=1[F:22].[C:23]([O:27][C:28]([NH:30][CH:31]1[CH2:34][NH:33][CH2:32]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>ClCCl>[C:23]([O:27][C:28]([NH:30][CH:31]1[CH2:32][N:33]([C:2]2[N:11]=[C:10]3[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][N:9]3[CH2:12][CH2:13][C:14]#[N:15])=[CH:4][C:3]=2[F:22])[CH2:34]1)=[O:29])([CH3:26])([CH3:24])[CH3:25]

Participants

4

Reactant 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 87333591HCID 87333591, compound

Product 1

HCID 67274679HCID 67274679, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of Example 7C (0.3 g) and 3-(tert-butoxycarbonylamino)azetidine (0.46 g) in dichloromethane (60 mL) was stirred for 2 hours, diluted with dichloromethane, washed with water, 10% citric acid, and brine, and dried (MgSO4), filtered, and concentrated.

Workup

  1. washwashed with water, 10% citric acid, and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-97f89316e5d545e59d6d4f1544990117
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

Loading…