反应详情

A solution of EXAMPLE 30B (130 mg) in trifluoroacetic acid (8 mL) was heated at 50° C. for 2 hours then cooled and concentrated. The concentrate was diluted with diethyl ether, stirred at ambient temperature for 4 hours, and filtered to provide the desired product. NMR (300 MHz, DMSO-d6) δ 14.05 (br s, 1H), 8.78 (s, 1H), 8.53 (m, 1H), 8.14 (m, 1H), 7.48 (m, 1H), 6.87 (m, 1H), 6.55 (s, 1H).

1. temperaturethen cooled
2. concentrationconcentrated
3. additionThe concentrate was diluted with diethyl ether
4. filtrationfiltered