HCID 67275508, compound → HCID 10469619, compound

HRID 1696914Notes

Reaction equation

HRID 1696914 reaction equation
C([N:5]1[C:14]2[C:9](=[CH:10][C:11]([F:21])=[C:12]([N:15]3[CH2:19][CH2:18][C@@H:17]([OH:20])[CH2:16]3)[N:13]=2)[C:8](=[O:22])[C:7]([C:23]([O:25]CC)=[O:24])=[CH:6]1)(C)(C)C>Cl>[F:21][C:11]1[CH:10]=[C:9]2[C:14](=[N:13][C:12]=1[N:15]1[CH2:19][CH2:18][C@@H:17]([OH:20])[CH2:16]1)[NH:5][CH:6]=[C:7]([C:23]([OH:25])=[O:24])[C:8]2=[O:22]

Participants

3

Reactant 1

HCID 67275508HCID 67275508, compound

Product 1

HCID 10469619HCID 10469619, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of Example 58A (100 mg) in 6M HCl (6 mL) was heated at 90° C. for 28 hours then cooled and concentrated; and the concentrate was recrystallized from methanol.

Workup

  1. temperaturethen cooled
  2. concentrationconcentrated
  3. customand the concentrate was recrystallized from methanol

Sources & evidence

ORD record
ord-c93f2cdab91e41ef9bc6f380134ba16e
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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