HCID 67275167, compound → HCID 10063738, compound

HRID 1696922Notes

Reaction equation

HRID 1696922 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:24]=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3CCC#N)=[CH:17][C:16]=2[F:33])[CH2:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[N:24]=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][NH:22]3)=[CH:17][C:16]=2[F:33])[CH2:11][CH2:10]1

Participants

3

Reactant 1

HCID 67275167HCID 67275167, compound

Product 1

HCID 10063738HCID 10063738, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Example 66B was treated with trifluoroacetic acid (20 mL), stirred for 10 minutes and concentrated; and the concentrate was azeotroped with toluene and dried under vacuum. NMR (300 MHz, DMSO-d6) δ 15.26 (s, 1H), 13.36 (br s, 1H), 8.57 (s, 1H), 8.09 (m, 1H), 7.91 (br s, 3H), 4.46 (m, 2H), 4.02 (br s, 1H), 3.22 (m, 2H), 2.04 (m, 2H), 1.61 (m, 2H).

Workup

  1. concentrationconcentrated
  2. customand the concentrate was azeotroped with toluene
  3. customdried under vacuum

Sources & evidence

ORD record
ord-250fcfacda574049aff3f9e52d6fae76
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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