HCID 67275189, compound → HCID 10015022, compound

HRID 1696923Notes

Reaction equation

HRID 1696923 reaction equation
C([N:5]1[C:14]2[C:9](=[CH:10][C:11]([F:18])=[C:12]([N:15]([CH3:17])[CH3:16])[N:13]=2)[C:8](=[O:19])[C:7]([C:20]([O:22]CC)=[O:21])=[CH:6]1)(C)(C)C>Cl>[CH3:16][N:15]([CH3:17])[C:12]1[N:13]=[C:14]2[C:9]([C:8](=[O:19])[C:7]([C:20]([OH:22])=[O:21])=[CH:6][NH:5]2)=[CH:10][C:11]=1[F:18]

Participants

3

Reactant 1

HCID 67275189HCID 67275189, compound

Product 1

HCID 10015022HCID 10015022, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of EXAMPLE 69A (155 mg) in 6M HCl (10 mL) was heated at 110° C. for 18 hours then cooled and filtered. NMR (300 MHz, CDCl3) δ 8.64 (d, 1H), 8.00 (d, 1H), 3.32 (d, 6H).

Workup

  1. temperaturethen cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-6646c0af2d53405abbd660ff3c20f0ed
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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