反应详情

温度

75 °C

A solution of EXAMPLE 81A (20 g) and 3-aminopropionitrile (4.9 mL) in 1:1 ethanol/diethyl ether (400 mL) was stirred for 15 minutes, diluted with hexanes (1 L), and filtered. The filtrant was dissolved in acetonitrile (400 mL), and the resulting solution was treated with potassium carbonate (17.4 g), heated at 75° C. for 18 hours then cooled, diluted with water (1.5 L), stirred for 1 hour, and filtered.

1. filtrationfiltered
2. dissolutionThe filtrant was dissolved in acetonitrile (400 mL)
3. additionthe resulting solution was treated with potassium carbonate (17.4 g)
4. temperaturethen cooled
5. additiondiluted with water (1.5 L)
6. filtrationfiltered