HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1696935Generated: October 31, 2026
3-Aminopropionitrile → Ethyl 7-chloro-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
https://huagongshe.com/reaction/1696935
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Aminopropionitrile | HCID 1647 | — |
| Reactant | Ethyl (2Z)-2-((2,6-dichloropyridin-3-yl)carbonyl)-3-(dimethylamino)prop-2-enoate | HCID 15675736 | — |
| Solvent | Diethyl ether ethanol | HCID 21585056 | — |
| Product | Ethyl 7-chloro-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | HCID 87333475 | — |
Reaction Steps
A solution of EXAMPLE 81A (20 g) and 3-aminopropionitrile (4.9 mL) in 1:1 ethanol/diethyl ether (400 mL) was stirred for 15 minutes, diluted with hexanes (1 L), and filtered. The filtrant was dissolved in acetonitrile (400 mL), and the resulting solution was treated with potassium carbonate (17.4 g), heated at 75° C. for 18 hours then cooled, diluted with water (1.5 L), stirred for 1 hour, and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163769B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-2d11fef41e544d75b34d55a10652b3f1 |
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| Source note | uspto-grants-2012_04 |
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