Hydrochloric Acid → HCID 67274886, compound

HRID 1696946Notes

Reaction equation

HRID 1696946 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:22][CH:21]([OH:23])[CH:20]([NH:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8](CCC#N)[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[CH2:25]([NH:24][C@H:20]1[C@@H:21]([OH:23])[CH2:22][N:18]([C:11]2[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][NH:8]3)=[CH:13][C:12]=2[F:17])[CH2:19]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67275341HCID 67275341, compound

Product 1

HCID 67274886HCID 67274886, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of EXAMPLE 199B (0.1 g) in ethanol (1 mL) at 25° C. was treated with 1N NaOH (1 mL), stirred for 18 hours at 50° C., cooled, neutralized with 10% HCl, and filtered.

Workup

  1. temperaturecooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-05416614aa0f435698b813729a626cd0
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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