N-(2-Aminoethyl)piperidine → N-{(1S,2R,3S,4R)-2,3-Dihydroxy-4-[6-[(naphthalen-1-ylmethyl)-amino]-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-cyclopentyl}-propionamide trifluoroacetate

Participants

Reaction Steps

This compound is prepared analogously to N-{(1S,2R,3S,4R)-4-[6-(2,2-diphenyl-ethylamino)-2-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (Example 16) by replacing N-{(1S,2R,3S,4R)-4-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (Example 4) with N-((1S,2R,3S,4R)-4-{2-chloro-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide trifluoroacetate (Example 50) and by replacing (S)-2-amino-3-phenyl-propan-1-ol with 2-piperidin-1-yl-ethylamine.

Provenance & Evidence