Ammonia → 4-Sulfamoylbenzaldehyde

HRID 1697063Notes

Reaction equation

HRID 1697063 reaction equation
[NH3:1].[CH:2]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)=[O:3]>C(Cl)Cl>[CH:2]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:1])(=[O:12])=[O:11])=[CH:6][CH:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27592104-Formylbenzene-1-sulfonyl chloride

Product 1

HCID 1510884-Sulfamoylbenzaldehyde

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of ammonia (0.5 M in 1,4-dioxane, 5 mL) was added to 4-formylbenzenesulfonyl chloride (0.5 g), followed by DCM (10 mL). The reaction mixture was stirred vigorously for 3 h at RT, then concentrated under reduced pressure. The crude residue was purified by flash chromatography to afford 4-formyl-benzenesulfonamide. MS=183.9 [M−H]−.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe crude residue was purified by flash chromatography

Sources & evidence

ORD record
ord-960ffd9a183d446db8976b3e3dbabf34
Source dataset
uspto-grants-2012_04
Patent number
US08163906B2

Reaction notes

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