HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 25182113, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 66816110 | HCID 66816110 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 25182113 | HCID 25182113 | — |
Reaction Steps
7-Chloro-4-oxo-1-phenyl-3-[4-(piperazine-1-sulfonyl)-benzyl]-1,4-dihydroquinoline-2-carboxylic acid methyl ester bishydrochloride (off-white powder) (compound 67) can be prepared utilizing HCl in 1,4-dioxane instead of TFA in DCM. MS=552 [M+H]+; MP=214.0-215.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163906B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-dd8e9359de6a4d93abe25faaa369a17b |
| Source note | uspto-grants-2012_04 |