Hydrochloric Acid → HCID 25182113, compound

HRID 1697079Notes

Reaction equation

HRID 1697079 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]([C:7]1[N:8]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:9]2[C:14]([C:15](=[O:33])[C:16]=1[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)(=[O:26])=[O:25])=[CH:20][CH:19]=1)=[CH:13][CH:12]=[C:11]([Cl:34])[CH:10]=2)=[O:6].Cl>O1CCOCC1.C(Cl)Cl>[CH3:3][O:4][C:5]([C:7]1[N:8]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:9]2[C:14]([C:15](=[O:33])[C:16]=1[CH2:17][C:18]1[CH:19]=[CH:20][C:21]([S:24]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)(=[O:26])=[O:25])=[CH:22][CH:23]=1)=[CH:13][CH:12]=[C:11]([Cl:34])[CH:10]=2)=[O:6]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66816110HCID 66816110, compound2×

Product 1

HCID 25182113HCID 25182113, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

7-Chloro-4-oxo-1-phenyl-3-[4-(piperazine-1-sulfonyl)-benzyl]-1,4-dihydroquinoline-2-carboxylic acid methyl ester bishydrochloride (off-white powder) (compound 67) can be prepared utilizing HCl in 1,4-dioxane instead of TFA in DCM. MS=552 [M+H]+; MP=214.0-215.5° C.

Sources & evidence

ORD record
ord-dd8e9359de6a4d93abe25faaa369a17b
Source dataset
uspto-grants-2012_04
Patent number
US08163906B2

Reaction notes

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