Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1697088생성일: 2026년 10월 25일
2-Oxopropanoyl chloride → N-(5-chloro-2-{3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide
https://huagongshe.com/reaction/1697088
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Oxopropanoyl chloride | HCID 521791 | — |
| 반응물 | 1-(4-Chloro-2-phenylamino-phenyl)-3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]propan-1-one | HCID 66816781 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-(5-chloro-2-{3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide | HCID 66817005 | — |
반응 단계
To 1-(4-chloro-2-phenylamino-phenyl)-3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]propan-1-one (0.200 g) in toluene (20 mL) was added 2-oxopropanoyl chloride (0.427 g). The reaction mixture was heated at 120° C. for 3 h, then stirred at RT overnight to produce N-(5-chloro-2-{3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide, which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08163906B2 |
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| 출처 데이터셋 | uspto-grants-2012_04 |
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| ORD ID | ord-4520d95aabbe4930829f415e6cea72d9 |
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| 출처 메모 | uspto-grants-2012_04 |
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