Ammonia → HCID 58496694, compound

HRID 1697275Notes

Reaction equation

HRID 1697275 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]([OH:25])=O)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH3:26]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH:12][C:13]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]([NH2:26])=[O:25])(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58496962HCID 58496962, compound

Product 1

HCID 58496694HCID 58496694, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

N,N′-carbonyldiimidazole are added to 1.13 g 5-(3,5-dichloro-phenylsulphonylamino)-naphthalene-1-carboxylic acid in 15 ml of tetrahydrofuran and the reaction mixture is stirred for 45 minutes at 60° C. Then ammonia gas is piped in at ambient temperature over a period of 25 minutes. The dark reaction solution is evaporated down using the rotary evaporator and the solid residue is stirred with water. Then it is acidified with 1 N hydrochloric acid and the precipitate formed is suction filtered, washed with water and dried in vacuo in the desiccator.

Workup

  1. customThe dark reaction solution is evaporated down
  2. customthe rotary evaporator
  3. stirringthe solid residue is stirred with water
  4. customthe precipitate formed
  5. filtrationfiltered
  6. washwashed with water
  7. customdried in vacuo in the desiccator

Sources & evidence

ORD record
ord-8a9ba3abd73d4c568a18cd91f47bddd5
Source dataset
uspto-grants-2012_04
Patent number
US08163911B2

Reaction notes

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