反应详情

温度

75 °C

To 3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide (Example 268e, 1.537 g) in ethanol (16 mL) was added ammonium formate (2.263 g) and 5% Pd/C (0.546 g) and the reaction heated at 75° C. for 1 h. The mixture was filtered through celite and the solid washed through with ethanol and dichloromethane. The filtrate was collected and the volatiles removed in vacuo. The residue was purified (SiO2 chromatography eluting with 0-30% diethyl ether in dichloromethane) to afford the subtitle product (0.874 g).

1. filtrationThe mixture was filtered through celite
2. washthe solid washed through with ethanol and dichloromethane
3. customThe filtrate was collected
4. customthe volatiles removed in vacuo
5. customThe residue was purified
6. wash(SiO2 chromatography eluting with 0-30% diethyl ether in dichloromethane)