(S)-alpha-(Trifluoromethyl)benzyl alcohol → HCID 46946222, compound

HRID 1697498Notes

Reaction equation

HRID 1697498 reaction equation
Cl.[C:2]([CH2:4][NH:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])(=[O:15])=[O:14])[CH2:10][NH:9]1)=[O:7])#[N:3].[C:23]1([CH:29](O)[C:30]([F:33])([F:32])[F:31])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:2]([CH2:4][NH:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])(=[O:14])=[O:15])[CH2:10][N:9]1[CH:29]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:30]([F:32])([F:31])[F:33])=[O:7])#[N:3]

Participants

3

Reactant 2

HCID 95556(S)-alpha-(Trifluoromethyl)benzyl alcoholHCID 86646813HCID 86646813, compound

Product 1

HCID 46946222HCID 46946222, compound

Procedure

L6. (2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid cyanomethyl-amide hydrochloride from experiment K1 was reacted with 1-phenyl-2,2,2-trifluoroethanol as described in experiment L5 to give (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(2,2,2-trifluoro-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid cyanomethyl-amide as a white amorphous solid. MS: 486.2 [M+H]+.

Sources & evidence

ORD record
ord-8eced90f9f724bc0af2f659c0dc2a5f7
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

Loading…