Benzoic Acid → HCID 59543520, compound

HRID 1697514Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]([C:10]1([NH:13][C:14]([C@@H:16]2[CH2:20][C@@H:19]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH2:18][NH:17]2)=[O:15])[CH2:12][CH2:11]1)#[N:9].[C:30](O)(=[O:37])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:8]([C:10]1([NH:13][C:14]([C@@H:16]2[CH2:20][C@@H:19]([S:21]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)(=[O:23])=[O:22])[CH2:18][N:17]2[C:30](=[O:37])[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:15])[CH2:12][CH2:11]1)#[N:9]

Participants

Reactant 2

HCID 243Benzoic Acid

HCID 66770358HCID 66770358, compound

Product 1

HCID 59543520HCID 59543520, compound

Procedure

L22. (2S,4R)-4-benzenesulfonyl-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide trifluoro-acetate from experiment K3 was coupled with benzoic acid in analogy to experiment A1 to give (2S,4R)-4-benzenesulfonyl-1-benzoyl-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as a pale yellow solid. MS: 424.2 [M+H]+.

Sources & evidence

ORD record: ord-fd55b715739a49e6bf95609629a240e3
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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