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HRID1697529

反应详情

EQUATION

反应方程式

HRID 1697529 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(C=O)C(F)(F)F
HCID2782188

3,3,3-trifluoro-2-methylpropanal

C4H5F3O

反应SMILES：Cl.N#CC1(NC(=O)[C@@H]2C[C@@H](S(=O)(=O)c3ccccc3Cl)CN2)CC1
HCID66770259

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(CN1C[C@H](S(=O)(=O)c2ccccc2Cl)C[C@H]1C(=O)NC1(C#N)CC1)C(F)(F)F
HCID46947018

未命名化合物

PROCEDURE

实验过程

(2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide hydrochloride from experiment K4 was reductively alkylated with rac-2-methyl-trifluoropropionaldehyde in analogy to experiment L3 to give (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3,3,3-trifluoro-2-methyl-propyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as a colorless solid. MS: 464.1 [M+H]+.