3,3,3-trifluoro-2-methylpropanal → HCID 46947018, compound

HRID 1697529Notes

Reaction equation

HRID 1697529 reaction equation
Cl.[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][NH:11]2)=[O:9])[CH2:6][CH2:5]1)#[N:3].[CH3:25][CH:26]([C:29]([F:32])([F:31])[F:30])[CH:27]=O>>[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][N:11]2[CH2:25][CH:26]([CH3:27])[C:29]([F:32])([F:31])[F:30])=[O:9])[CH2:6][CH2:5]1)#[N:3]

Participants

3

Reactant 2

HCID 27821883,3,3-trifluoro-2-methylpropanalHCID 66770259HCID 66770259, compound

Product 1

HCID 46947018HCID 46947018, compound

Procedure

(2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide hydrochloride from experiment K4 was reductively alkylated with rac-2-methyl-trifluoropropionaldehyde in analogy to experiment L3 to give (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3,3,3-trifluoro-2-methyl-propyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as a colorless solid. MS: 464.1 [M+H]+.

Sources & evidence

ORD record
ord-553bc8e45ecc49cbaef6e9aeb425c5a3
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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