Lithium Hydroxide → (2S,4R)-4-(4-Fluoro-2-trifluoromethyl-benzenesulfonyl)-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid

HRID 1697578Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1697578
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[C:20]([F:23])([F:22])[F:21])(=[O:12])=[O:11])[CH2:7][N:6]1[C:24]1[N:25]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=2)[N:26]=[C:27]([CH3:29])[CH:28]=1)=[O:4].[OH-].[Li+]>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([S:10]([C@H:8]2[CH2:7][N:6]([C:24]3[N:25]([C:30]4[CH:31]=[CH:32][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:34][CH:35]=4)[N:26]=[C:27]([CH3:29])[CH:28]=3)[C@H:5]([C:3]([OH:4])=[O:2])[CH2:9]2)(=[O:12])=[O:11])=[C:14]([C:20]([F:23])([F:21])[F:22])[CH:15]=1

Komponenten

3

Edukt 2

HCID 3939Lithium HydroxideHCID 86646832(2S,4R)-4-(4-Fluoro-2-trifluoromethyl-benzenesulfonyl)-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

Produkt 1

HCID 86646833(2S,4R)-4-(4-Fluoro-2-trifluoromethyl-benzenesulfonyl)-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid

Versuchsvorschrift

In analogy to the procedure described in example 253e, (2S,4R)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-1-[5-methyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow oil. MS (ESI): m/z=566.1 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-06fc360c6eab41eab7ebf5c14cc1c922
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163793B2

Notizen zur Reaktion

Wird geladen…