HRID1697598

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccc(OCC(F)(F)F)cc2C(F)(F)F)CN1c1cc(C)nn1C(C)C

HCID86646839

未命名化合物

HCID86646842

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(N2C[C@H](S(=O)(=O)c3ccc(OCC(F)(F)F)cc3C(F)(F)F)C[C@H]2C(=O)O)n(C(C)C)n1

HCID86646841

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 253e, a mixture of (2S,4R)-1-(2-isopropyl-5-methyl-2H-pyrazol-3-yl)-4-[4-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-benzenesulfonyl]-pyrrolidine-2-carboxylic acid methyl ester and (2R,4R)-1-(2-isopropyl-5-methyl-2H-pyrazol-3-yl)-4-[4-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-benzenesulfonyl]-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as colorless solid. MS (ESI): m/z=544.2 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-edacd0132a9749c6b0878633f6bfc1d9
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08163793B2
来源说明: uspto-grants-2012_04

反应 SMILES

C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:15][C:14]=2[C:25]([F:28])([F:27])[F:26])(=[O:12])=[O:11])[CH2:7][N:6]1[C:29]1[N:30]([CH:35]([CH3:37])[CH3:36])[N:31]=[C:32]([CH3:34])[CH:33]=1)=[O:4].COC([C@H]1C[C@@H](S(C2C=CC(OCC(F)(F)F)=CC=2C(F)(F)F)(=O)=O)CN1C1N(C(C)C)N=C(C)C=1)=O.[OH-].[Li+]>>[CH:35]([N:30]1[C:29]([N:6]2[CH2:7][C@H:8]([S:10]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])=[CH:15][C:14]=3[C:25]([F:28])([F:27])[F:26])(=[O:12])=[O:11])[CH2:9][C@H:5]2[C:3]([OH:4])=[O:2])=[CH:33][C:32]([CH3:34])=[N:31]1)([CH3:37])[CH3:36]