tert-Butylhydrazine monohydrochloride → HCID 66770715, compound

HRID 1697612Notes

Reaction equation

[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=S)[CH2:24][C:25](=O)[CH3:26])=[O:4].Cl.[C:30]([NH:34][NH2:35])([CH3:33])([CH3:32])[CH3:31]>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:21])([F:22])[F:20])(=[O:11])=[O:12])[CH2:7][N:6]1[C:23]1[N:34]([C:30]([CH3:33])([CH3:32])[CH3:31])[N:35]=[C:25]([CH3:26])[CH:24]=1)=[O:4]

Participants

Reactant 2

HCID 81889tert-Butylhydrazine monohydrochloride

HCID 86646823(2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

Product 1

HCID 66770715HCID 66770715, compound

Procedure

In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with tert-butylhydrazine hydrochloride (CAS Reg. No. 7400-27-3) to give the title compound as brown solid. MS (ESI): m/z=474.2 [M+H]+.

Sources & evidence

ORD record: ord-a7be6ae2539d4c15bab1f9ea15ea2a64
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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