Lithium Hydroxide → 1-(2-tert-Butyl-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid
Reaction equation
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])(=[O:13])=[O:12])[CH2:8][N:7]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:30]([CH3:33])([CH3:32])[CH3:31])=[O:5])C.[OH-].[Li+]>>[C:30]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[N:7]1[CH2:8][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:22])([F:23])[F:21])(=[O:13])=[O:12])[CH2:10][CH:6]1[C:4]([OH:5])=[O:3])([CH3:33])([CH3:31])[CH3:32]Participants
3
Procedure
In analogy to the procedure described in example 253e, 1-(2-tert-butyl-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as off-white solid which was used in the next step without further purification. MS (ESI): m/z=456.2 [M+H]+.
Sources & evidence
- ORD record
- ord-93ae9c14ebb7465bae4c12da3e151a07
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08163793B2
Reaction notes
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