Lithium Hydroxide → 1-(3-Cyano-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid
Reaction equation
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])(=[O:13])=[O:12])[CH2:8][N:7]1[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[N:31])[CH:25]=1)=[O:5])C.[OH-].[Li+]>>[C:30]([C:26]1[CH:25]=[C:24]([N:7]2[CH2:8][CH:9]([S:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]([F:21])([F:22])[F:23])(=[O:12])=[O:13])[CH2:10][CH:6]2[C:4]([OH:5])=[O:3])[CH:29]=[CH:28][CH:27]=1)#[N:31]Participants
3
Procedure
In analogy to the procedure described in example 253e, 1-(3-cyano-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as off-white solid which was used in the next step without further purification. MS (ESI): m/z=425.1 [M+H]+.
Sources & evidence
- ORD record
- ord-63c3c9f9c4ac411b99c5885a34048056
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08163793B2
Reaction notes
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