Lithium Hydroxide → HCID 66770725, compound

HRID 1697641Notes

Reaction equation

C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])(=[O:13])=[O:12])[CH2:8][N:7]1[CH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)=[O:5])C.[OH-].[Li+]>>[O:27]1[CH2:26][CH2:25][CH:24]([N:7]2[CH2:8][CH:9]([S:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]([F:22])([F:23])[F:21])(=[O:13])=[O:12])[CH2:10][CH:6]2[C:4]([OH:5])=[O:3])[CH2:29][CH2:28]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66770566HCID 66770566, compound

Product 1

HCID 66770725HCID 66770725, compound

Procedure

In analogy to the procedure described in example 253e, 1-(tetrahydro-pyran-4-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as white solid which was used in the next step without further purification. MS (ESI): m/z=408.4 [M+H]+.

Sources & evidence

ORD record: ord-333c686164d14a0ab239d8e5572c2b4d
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

Loading…