Lithium Hydroxide → HCID 86646854, compound

HRID 1697649Notes

Reaction equation

C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])(=[O:13])=[O:12])[CH2:8][N:7]1[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]([F:34])([F:33])[F:32])[CH:25]=1)=[O:5])C.[OH-].[Li+]>>[F:34][C:31]([F:32])([F:33])[O:30][C:26]1[CH:25]=[C:24]([N:7]2[CH2:8][CH:9]([S:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]([F:21])([F:22])[F:23])(=[O:13])=[O:12])[CH2:10][CH:6]2[C:4]([OH:5])=[O:3])[CH:29]=[CH:28][CH:27]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86646853HCID 86646853, compound

Product 1

HCID 86646854HCID 86646854, compound

Procedure

In analogy to the procedure described in example 253e, 1-(3-trifluoromethoxy-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow oil which was used in the next step without further purification. MS (ESI): m/z=484.2 [M+H]+.

Sources & evidence

ORD record: ord-2b31e8c8caca4dc4b8fd70e699e0989e
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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