Formaldehyde → 1-(3-Chloro-4-fluoro-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester

HRID 1697670Notes

Reaction equation

HRID 1697670 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([Cl:14])[CH:8]=1)[CH3:2].[CH2:16]=O.[CH:18]([S:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]([F:32])([F:31])[F:30])(=[O:22])=[O:21])=[CH2:19]>>[CH2:1]([O:3][C:4]([CH:5]1[CH2:16][CH:18]([S:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[C:29]([F:30])([F:32])[F:31])(=[O:21])=[O:22])[CH2:19][N:6]1[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([Cl:14])[CH:8]=1)=[O:15])[CH3:2]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 302640Ethyl 2-(3-chloro-4-fluoroanilino)acetateHCID 234667181-Ethenesulfonyl-2-trifluoromethyl-benzene

Product 1

HCID 667709071-(3-Chloro-4-fluoro-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester

Procedure

In analogy to the procedure described in example 343d, (3-chloro-4-fluoro-phenylamino)-acetic acid ethyl ester (CAS Reg. No. 2344-98-1) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as off-white solid.

Sources & evidence

ORD record
ord-a0d05ce62f03495499bc92096c73a522
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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