HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1-(3-Chloro-4-fluoro-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Ethyl 2-(3-chloro-4-fluoroanilino)acetate | HCID 302640 | — |
| Reactant | 1-Ethenesulfonyl-2-trifluoromethyl-benzene | HCID 23466718 | — |
| Product | 1-(3-Chloro-4-fluoro-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Ethyl Ester | HCID 66770907 | — |
Reaction Steps
In analogy to the procedure described in example 343d, (3-chloro-4-fluoro-phenylamino)-acetic acid ethyl ester (CAS Reg. No. 2344-98-1) was reacted with paraformaldehyde and 1-ethenesulfonyl-2-trifluoromethyl-benzene (example 243c) to give the title compound as off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a0d05ce62f03495499bc92096c73a522 |
| Source note | uspto-grants-2012_04 |