Lithium Hydroxide → HCID 66770915, compound

HRID 1697686Notes

Reaction equation

C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])(=[O:13])=[O:12])[CH2:8][N:7]1[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([S:30]([CH3:33])(=[O:32])=[O:31])[CH:25]=1)=[O:5])C.[OH-].[Li+]>>[CH3:33][S:30]([C:26]1[CH:25]=[C:24]([N:7]2[CH2:8][CH:9]([S:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:20]([F:22])([F:23])[F:21])(=[O:12])=[O:13])[CH2:10][CH:6]2[C:4]([OH:5])=[O:3])[CH:29]=[CH:28][CH:27]=1)(=[O:31])=[O:32]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66771234HCID 66771234, compound

Product 1

HCID 66770915HCID 66770915, compound

Procedure

In analogy to the procedure described in example 253e, 1-(3-methanesulfonyl-phenyl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as white solid which was used in the next step without further purification. MS (ESI): m/z=476.1 [M−H]−.

Sources & evidence

ORD record: ord-d381649315964ce5b40d065be84f5b43
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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