HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-{5-[(2S,4R)-2-Carboxy-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 4-{5-[(2S,4R)-2-Methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester | HCID 66770398 | — |
| Product | 4-{5-[(2S,4R)-2-Carboxy-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester | HCID 66771196 | — |
Reaction Steps
In analogy to the procedure described in example 253e, 4-{5-[(2S,4R)-2-methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic acid benzyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow solid. MS (ESI): m/z=619.4 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-d8fa13b0f20741a0b234ffdf08a46876 |
| Source note | uspto-grants-2012_04 |