HRID1697692

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2C(F)(F)F)CN1c1cc(C)nn1C1CCN(C(=O)OCc2ccccc2)CC1

HCID66770398

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3C(F)(F)F)C[C@H]2C(=O)O)n(C2CCN(C(=O)OCc3ccccc3)CC2)n1

HCID66771196

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 253e, 4-{5-[(2S,4R)-2-methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic acid benzyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow solid. MS (ESI): m/z=619.4 [M−H]−.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d8fa13b0f20741a0b234ffdf08a46876
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08163793B2
来源说明: uspto-grants-2012_04

反应 SMILES

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[C:21]([N:22]3[CH2:26][C@H:25]([S:27]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=4[C:36]([F:39])([F:38])[F:37])(=[O:29])=[O:28])[CH2:24][C@H:23]3[C:40]([O:42]C)=[O:41])=[CH:20][C:19]([CH3:44])=[N:18]2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Li+]>>[CH2:1]([O:8][C:9]([N:11]1[CH2:12][CH2:13][CH:14]([N:17]2[C:21]([N:22]3[CH2:26][C@H:25]([S:27]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=4[C:36]([F:37])([F:38])[F:39])(=[O:29])=[O:28])[CH2:24][C@H:23]3[C:40]([OH:42])=[O:41])=[CH:20][C:19]([CH3:44])=[N:18]2)[CH2:15][CH2:16]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1