Lithium Hydroxide → (2S,4R)-1-Pyrimidin-2-yl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid
Reaction equation
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23]1[N:28]=[CH:27][CH:26]=[CH:25][N:24]=1)=[O:4].[OH-].[Li+]>>[N:24]1[CH:25]=[CH:26][CH:27]=[N:28][C:23]=1[N:6]1[CH2:7][C@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:20])([F:21])[F:22])(=[O:12])=[O:11])[CH2:9][C@H:5]1[C:3]([OH:4])=[O:2]Participants
3
Procedure
In analogy to the procedure described in example 253e, (2S,4R)-1-pyrimidin-2-yl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as white solid. MS (ESI): m/z=402.1 [M+H]+.
Sources & evidence
- ORD record
- ord-91801f9ed9ce46af885034f311430fc3
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08163793B2
Reaction notes
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