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HRID1697704

反应详情

EQUATION

反应方程式

HRID 1697704 的结构方程式

REACTANTS

反应物

2
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@@H]1C[C@@H](S(=O)(=O)c2ccccc2Cl)CN1c1cc(C)nn1Cc1ccc(Cl)cc1
HCID67277851

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(N2C[C@H](S(=O)(=O)c3ccccc3Cl)C[C@H]2C(=O)O)n(Cc2ccc(Cl)cc2)n1
HCID66770880

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 253e, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-[2-(4-chloro-benzyl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as off-white solid which was used in the next step without further purification. MS (ESI): m/z=494.1 [M+H]+.