Lithium Hydroxide → HCID 66771203, compound

HRID 1697707Notes

Reaction equation

C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[C:20]([F:23])([F:22])[F:21])(=[O:12])=[O:11])[CH2:7][N:6]1[C:24]1[N:25]([CH:30]2[CH2:33][CH2:32][CH2:31]2)[N:26]=[C:27]([CH3:29])[CH:28]=1)=[O:4].[OH-].[Li+]>>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([S:10]([C@H:8]2[CH2:7][N:6]([C:24]3[N:25]([CH:30]4[CH2:33][CH2:32][CH2:31]4)[N:26]=[C:27]([CH3:29])[CH:28]=3)[C@H:5]([C:3]([OH:4])=[O:2])[CH2:9]2)(=[O:12])=[O:11])=[C:14]([C:20]([F:23])([F:21])[F:22])[CH:15]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 67278578HCID 67278578, compound

Product 1

HCID 66771203HCID 66771203, compound

Procedure

In analogy to the procedure described in example 253e, (2S,4R)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-1-(2-cyclobutyl-5-methyl-2H-pyrazol-3-yl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound brown solid which was used in the next step without further purification. MS (ESI): m/z=538.1 [M+H]+.

Sources & evidence

ORD record: ord-06eebd57c4104c8cbdc142007a0f6e86
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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