Lithium Hydroxide → HCID 66770718, compound

HRID 1697712Notes

Reaction equation

C([O:3][C:4]([C:6]1([CH2:30][CH2:31][S:32]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)(=[O:34])=[O:33])[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:8]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:22][CH:21]=2)[NH:7]1)=[O:5])C.[OH-].[Li+]>>[C:14]1([S:11]([CH:9]2[CH:8]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([CH3:29])([CH3:27])[CH3:28])=[CH:22][CH:21]=3)[NH:7][C:6]([CH2:30][CH2:31][S:32]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)(=[O:34])=[O:33])([C:4]([OH:5])=[O:3])[CH2:10]2)(=[O:12])=[O:13])[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66770467HCID 66770467, compound

Product 1

HCID 66770718HCID 66770718, compound

Procedure

In analogy to the procedure described in example 253e, 4-benzenesulfonyl-2-(2-benzenesulfonyl-ethyl)-5-(4-tert-butyl-phenyl)-pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow solid which was used in the next step without further purification. MS (ESI): m/z=556.2 [M+H]+.

Sources & evidence

ORD record: ord-a2393dc7ca4d4f8c90bc244f430537b5
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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