Lithium Hydroxide → HCID 66770941, compound

HRID 1697727Notes

Reaction equation

C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([CH2:13][CH:14]2[CH2:16][CH2:15]2)(=[O:12])=[O:11])[CH2:7][N:6]1[C:17]([C:19]1([CH3:22])[CH2:21][CH2:20]1)=[O:18])=[O:4].[OH-].[Li+]>>[CH:14]1([CH2:13][S:10]([C@H:8]2[CH2:7][N:6]([C:17]([C:19]3([CH3:22])[CH2:20][CH2:21]3)=[O:18])[C@H:5]([C:3]([OH:4])=[O:2])[CH2:9]2)(=[O:11])=[O:12])[CH2:15][CH2:16]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66771062HCID 66771062, compound

Product 1

HCID 66770941HCID 66770941, compound

Procedure

In analogy to the procedure described in example 253e, (2S,4R)-4-cyclopropylmethanesulfonyl-1-(1-methyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound which was used in the next step without further purification.

Sources & evidence

ORD record: ord-b34b2a6cb7954e06995835f671076e40
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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