2,2,2-Trifluoroethanol → 2,2,2-Trifluoroethanol

HRID 1697773Notes

Reaction equation

HRID 1697773 reaction equation
[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:11][N:10]2[C:25]2[N:26]([CH:31]3[CH2:34][CH2:33][CH2:32]3)[N:27]=[C:28]([CH3:30])[CH:29]=2)=[O:8])[CH2:5][CH2:4]1)#[N:2].[F:35][C:36]([F:40])([F:39])[CH2:37][OH:38]>>[CH2:37]([OH:38])[C:36]([F:40])([F:39])[F:35].[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([O:38][CH2:37][C:36]([F:40])([F:39])[F:35])=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:11][N:10]2[C:25]2[N:26]([CH:31]3[CH2:32][CH2:33][CH2:34]3)[N:27]=[C:28]([CH3:30])[CH:29]=2)=[O:8])[CH2:4][CH2:5]1)#[N:2]

Participants

4

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 66770817HCID 66770817, compound

Product 2

HCID 64092,2,2-TrifluoroethanolHCID 59543552HCID 59543552, compound

Procedure

In analogy to the procedure described in example 392, (2S,4R)-4-(2-chloro-4-fluoro-benzenesulfonyl)-1-(2-cyclobutyl-5-methyl-2H-pyrazol-3-yl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide (example 385b) was reacted with 2,2,2,-trifluoroethanol (CAS Reg. No. 75-89-8 99) to give the title compound as colorless solid. MS (ESI): m/z=586.0 [M+H]+.

Sources & evidence

ORD record
ord-24e4c20e2d9342e6bc64b4d1517782e3
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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