Phenelzine Sulfate → HCID 66772109, Verbindung

HRID 1697776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1697776
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([C@H:12]1[CH2:16][N:15]([C:17](=S)[CH2:18][C:19](=O)[CH3:20])[C@H:14]([C:23]([O:25][CH3:26])=[O:24])[CH2:13]1)(=[O:11])=[O:10].S(O)(O)(=O)=O.[CH2:32]([NH:40][NH2:41])[CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH3:26][O:25][C:23]([C@@H:14]1[CH2:13][C@@H:12]([S:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[Cl:1])(=[O:11])=[O:10])[CH2:16][N:15]1[C:17]1[N:40]([CH2:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[N:41]=[C:19]([CH3:20])[CH:18]=1)=[O:24]

Komponenten

3

Edukt 2

HCID 61100Phenelzine SulfateHCID 86646870(2S,4R)-Methyl 4-(2-chloro-4-fluorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate

Produkt 1

HCID 66772109HCID 66772109, Verbindung

Versuchsvorschrift

In analogy to the procedure described in example 192 h, (2S,4R)-methyl 4-(2-chloro-4-fluorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate (example 464 a) was reacted with 2-phenethyl-hydrazine sulfate (CAS Reg. No. 56-51-4) to give the title compound as yellow oil. MS (ESI): m/z=506.1 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-32fe98574e1c47d5a7f3e34de30a95d8
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08163793B2

Notizen zur Reaktion

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