2,2,2-Trifluoroethanol → 2,2,2-Trifluoroethanol

HRID 1697779Notes

Reaction equation

HRID 1697779 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[S:9]([C@H:12]1[CH2:16][N:15]([C:17]2[N:21]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:20]=[C:19]([CH3:30])[CH:18]=2)[C@H:14]([C:31]([NH:33][C:34]2([C:37]#[N:38])[CH2:36][CH2:35]2)=[O:32])[CH2:13]1)(=[O:11])=[O:10].[F:39][C:40]([F:44])([F:43])[CH2:41][OH:42]>>[CH2:41]([OH:42])[C:40]([F:44])([F:43])[F:39].[C:37]([C:34]1([NH:33][C:31]([C@@H:14]2[CH2:13][C@@H:12]([S:9]([C:3]3[CH:4]=[CH:5][C:6]([O:42][CH2:41][C:40]([F:44])([F:43])[F:39])=[CH:7][C:2]=3[Cl:1])(=[O:11])=[O:10])[CH2:16][N:15]2[C:17]2[N:21]([CH2:22][CH2:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:20]=[C:19]([CH3:30])[CH:18]=2)=[O:32])[CH2:35][CH2:36]1)#[N:38]

Participants

4

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 59543745HCID 59543745, compound

Product 2

HCID 64092,2,2-TrifluoroethanolHCID 59543736HCID 59543736, compound

Procedure

In analogy to the procedure described in example 392, (2S,4R)-4-(2-chloro-4-fluorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(3-methyl-1-phenethyl-1H-pyrazol-5-yl)pyrrolidine-2-carboxamide (example 484c) was reacted with 2,2,2,-trifluoroethanol (CAS Reg. No. 75-89-8 99) to give the title compound as colorless oil. MS (ESI): m/z=636.2 [M+H]+.

Sources & evidence

ORD record
ord-ddc64896f53b49e5a00da3d46e83cffe
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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