Dichloro-1,2,4-thiadiazole → (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-(3-chloro-[1,2,4]thiadiazol-5-yl)-pyrrolidine-2-carboxylic Acid Methyl Ester

Participants

Reaction Steps

In analogy to the procedure described in example 335a, (2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 253a) was reacted with 3,5-dichloro-[1,2,4]thiadiazole (CAS Reg. No. 2254-88-8) in a shaking reactor at 55° C. for 48 h to give the title compound as red oil. MS (ESI): m/z=422.0 [M+H]+.

Provenance & Evidence