Pyrazole → HCID 72321967, compound

HRID 1697786Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6](F)[CH:5]=[CH:4][C:3]=1[S:9]([C@H:12]1[CH2:16][N:15]([C:17]2[N:21]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[N:20]=[C:19]([CH3:28])[CH:18]=2)[C@H:14]([C:29]([NH:31][C:32]2([C:35]#[N:36])[CH2:34][CH2:33]2)=[O:30])[CH2:13]1)(=[O:11])=[O:10].[NH:37]1[CH:41]=[CH:40][CH:39]=[N:38]1>>[C:35]([C:32]1([NH:31][C:29]([CH:14]2[CH2:13][CH:12]([S:9]([C:3]3[CH:4]=[CH:5][C:6]([N:37]4[CH:41]=[CH:40][CH:39]=[N:38]4)=[CH:7][C:2]=3[Cl:1])(=[O:11])=[O:10])[CH2:16][N:15]2[C:17]2[N:21]([CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[N:20]=[C:19]([CH3:28])[CH:18]=2)=[O:30])[CH2:34][CH2:33]1)#[N:36]

Participants

Reactant 2

HCID 1048Pyrazole

HCID 59543671HCID 59543671, compound

Product 1

HCID 72321967HCID 72321967, compound

Procedure

In analogy to the procedure described in example 416, (2S,4R)-4-(2-chloro-4-fluorophenylsulfonyl)-N-(1-cyanocyclopropyl)-1-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxamide (example 464d) was reacted with pyrazole (CAS Reg. No. 288-11-9) to give the title compound as colorless oil. MS (ESI): m/z=584.2 [M+H]+.

Sources & evidence

ORD record: ord-bbd7403924614b49af82216e4be5f949
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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