HRID1697944

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75646

Cyclopropanemethanamine

C4H9N

HCID137254

1-Methyl-3-aminopyrazole

C4H7N3

结构：C[C@H]1COCCN1c1nc(-c2ccc(N)cc2)nc2c1CCN(c1ncccn1)C2

HCID67176513

未命名化合物

结构：Nc1ccc(-c2nc3c(c(N4CCOCC4)n2)CNC(c2ncccn2)C3)cc1

HCID67177223

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccn(C)n3)cc2)nc2c1CCN(c1ncccn1)C2

HCID59239519

未命名化合物

PROCEDURE

实验过程

The title compound lg was prepared by the general procedure of Example 30 substituting (S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline for 4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline and 1-methyl-1H-pyrazole-3-amine for cyclopropylmethylamine. LC-MS: m/z=+527 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ef7f36a6d3ca483d95c3a99361356b87
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08163763B2
来源说明: uspto-grants-2012_04

反应 SMILES

[CH3:1][C@@H:2]1[N:7]([C:8]2[C:9]3[CH2:24][CH2:23][N:22]([C:25]4[N:30]=[CH:29][CH:28]=[CH:27][N:26]=4)[CH2:21][C:10]=3[N:11]=[C:12]([C:14]3[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=3)[N:13]=2)[CH2:6][CH2:5][O:4][CH2:3]1.[O:31]1CCN(C2C3CNC(C4N=CC=CN=4)CC=3N=C(C3C=CC(N)=CC=3)N=2)C[CH2:32]1.[CH3:60][N:61]1[CH:65]=[CH:64][C:63]([NH2:66])=[N:62]1.C1(CN)CC1>>[CH3:60][N:61]1[CH:65]=[CH:64][C:63]([NH:66][C:32]([NH:18][C:17]2[CH:19]=[CH:20][C:14]([C:12]3[N:13]=[C:8]([N:7]4[CH2:6][CH2:5][O:4][CH2:3][C@@H:2]4[CH3:1])[C:9]4[CH2:24][CH2:23][N:22]([C:25]5[N:26]=[CH:27][CH:28]=[CH:29][N:30]=5)[CH2:21][C:10]=4[N:11]=3)=[CH:15][CH:16]=2)=[O:31])=[N:62]1