HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanamine → (S)-1-(1-methyl-1H-pyrazol-3-yl)-3-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanamine | HCID 75646 | — |
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Reactant | (S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline | HCID 67176513 | — |
| Reactant | 4-(4-Morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline | HCID 67177223 | — |
| Product | (S)-1-(1-methyl-1H-pyrazol-3-yl)-3-(4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea | HCID 59239519 | — |
Reaction Steps
The title compound lg was prepared by the general procedure of Example 30 substituting (S)-4-(4-(3-methylmorpholino)-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)aniline for 4-(4-morpholino-7-(pyrimidin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)aniline and 1-methyl-1H-pyrazole-3-amine for cyclopropylmethylamine. LC-MS: m/z=+527 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163763B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-ef7f36a6d3ca483d95c3a99361356b87 |
| Source note | uspto-grants-2012_04 |