5-Bromo-1-methylpyridin-2(1H)-one → HCID 59239068, compound

HRID 1697960Notes

Reaction equation

HRID 1697960 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].Br[C:30]1[CH:31]=[CH:32][C:33](=[O:37])[N:34]([CH3:36])[CH:35]=1>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:24][CH2:25][O:26][CH2:27][CH2:28]3)[C:16]3[CH2:22][CH2:21][N:20]([C:30]4[CH:31]=[CH:32][C:33](=[O:37])[N:34]([CH3:36])[CH:35]=4)[CH2:19][C:17]=3[N:18]=2)=[CH:11][CH:12]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 130240275-Bromo-1-methylpyridin-2(1H)-oneHCID 469130711-Ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl) phenyl)urea

Product 1

HCID 59239068HCID 59239068, compound

Procedure

The compound was prepared following the general procedure in Example 289, substituting 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline for 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea and substituting 2-Bromo-6-benzyloxypyridine for 5-bromo-1-methylpyridin-2(1H)-one: LC-MS m/z=490 (M+H).

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-d24d854592cd4fe7b384ad556905692c
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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