Sodium Iodide → HCID 59239158, compound

HRID 1697967Notes

Reaction equation

HRID 1697967 reaction equation
Cl.[CH2:2]([NH:4][C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[C:16]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[C:17]3[CH2:23][CH2:22][NH:21][CH:20]([CH3:24])[C:18]=3[N:19]=2)=[CH:10][CH:9]=1)=[O:6])[CH3:3].Br[CH2:32][CH:33]1[O:37][CH2:36][CH2:35][O:34]1.[I-].[Na+]>>[O:34]1[CH2:35][CH2:36][O:37][CH:33]1[CH2:32][N:21]1[CH2:22][CH2:23][C:17]2[C:16]([N:25]3[CH2:26][CH2:27][O:28][CH2:29][CH2:30]3)=[N:15][C:14]([C:11]3[CH:10]=[CH:9][C:8]([NH:7][C:5]([NH:4][CH2:2][CH3:3])=[O:6])=[CH:13][CH:12]=3)=[N:19][C:18]=2[CH:20]1[CH3:24]

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 780681,3-Dioxolane, 2-(bromomethyl)-HCID 67176741HCID 67176741, compound

Product 1

HCID 59239158HCID 59239158, compound

Procedure

The compound sj was prepared following the general procedure in Example 296, substituting 1-ethyl-3-(4-(4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt for 1-ethyl-3-(4-(8-methyl-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride salt and substituting 1-bromo-2-methoxyethane for 2-(bromomethyl)-1,3-dioxolane. For this reaction, a catalytic amount Sodium iodide was also added: LC-MS m/z=483 (M+H).

Workup

  1. customThe compound sj was prepared
  2. customFor this reaction

Sources & evidence

ORD record
ord-85109a24c31945499234ca374169a06d
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

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