反应详情

温度

80 °C

Triethylamine (1.94 mL, 13.9 mmol) and diphenylphosphoryl azide (2.76 mL, 12.8 mmol) were added to a solution of 2-bromo-1,3-benzothiazole-6-carboxylic acid (3.0 g, 11.6 mmol) in tert-butanol (100 mL) and the reaction mixture was stirred at 80° C. for 4 h. The solvent was evaporated under reduced pressure and the residue was subjected to flash chromatography (Heptane/EtOAc gradient) to give tert-butyl (2-bromo-1,3-benzothiazol-6-yl)carbamate (1.1 g) as a white solid. MS m/z (M+H) 329, 331.

1. customThe solvent was evaporated under reduced pressure