Diethylamine → HCID 59278268, compound

HRID 1698195Notes

Reaction equation

HRID 1698195 reaction equation
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:25]([O:27][CH3:28])=[O:26])[C@@H:3]([CH3:24])[O:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(NCC)C>C(#N)C>[NH2:1][C@H:2]([C:25]([O:27][CH3:28])=[O:26])[C@@H:3]([CH3:24])[O:4][C:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 59278391HCID 59278391, compound

Product 1

HCID 59278268HCID 59278268, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of Fmoc-L-Thr(Trt)-OMe (2.40 g, 4.00 mmol) in acetonitrile (20.0 mL) was added diethylamine (20.0 mL). After 30 minutes, the mixture was concentrated in vacuo and the residue was diluted with acetonitrile (3×10 mL) and azeotroped in vacuo to afford L-Thr(Trt)-OMe which was used without further purification.

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. additionthe residue was diluted with acetonitrile (3×10 mL)
  3. customazeotroped in vacuo

Sources & evidence

ORD record
ord-691547fe63e5476a9be8879de24b1f79
Source dataset
uspto-grants-2012_04
Patent number
US08163918B2

Reaction notes

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